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雷艳丽

:雷艳丽

讲师

导师资格:硕士生导师

箱:leiyanli222@126.com

话:15111429554

研究方向:功能核酸探针的设计与生化分析应用、疾病诊断与治疗、食品安全分析

简介:雷艳丽,理学博士,讲师,硕士生导师。201810月毕业于湖南大学分析化学专业,20191月起加入长沙理工大学。目前主持承担国家自然科学基金青年项目、湖南省自然科学基金青年项目、湖南省教育厅一般项目、化学生物传感与计量学国家重点实验室开发基金等多项研究课题。已在Angewandte ChemieTheranosticsAnal. Chem.Chem. Commun.等期刊发表论文20余篇,申请发明专利2项。

主持及参与科研项目

(1)国家自然科学基金项目,青年项目,32202170,基于DNA水凝胶的液柱式传感器对生鲜肉品新鲜度的精准无损监测研究,2023-012025-1230万元,在研,主持。

(2)湖南省自然科学基金委员会,青年项目,2020JJ5568,裂开式核酸适配体介导的肝癌荧光成像与免疫治疗研究,2020-012022-125万元,结题,主持;

(3)化学生物传感与计量学国家重点实验室开放课题,2019013,裂开式aptamer诊疗探针介导NK细胞的肿瘤免疫治疗研究,2020-052022-043万元,在研,主持;

(4)湖南省教育厅科学研究项目,一般项目,19C0076,基于裂开式脱氧核酶的肿瘤微区重组型诊疗体系构建及其应用研究,2019-092021-092万元,结题,主持;

代表性论文:

(1)Yanli Lei, Jinlu Tang, Xiaoxiao He, Hui Shi,* Yu Zeng, Haiyan Sun, and Kemin Wang*. In Situ Modulating DNAzyme Activity and Internalization Behavior with Acid-Initiated Reconfigurable DNA Nanodevice for Activatable Theranostic.Analytical Chemistry, 2021, 93, 5629-5634.

(2) Lihua Zhang, Zhen Zou,Yanli Lei,* Zhihe Qing, Yu Zeng, Haiyan Sun, Feng Feng* and Ronghua Yang*. Bidirectional modulation of microRNA with a clamp-like triplex switch for enhanced and programmed gene therapy.Chemical Communications, 2021, 57, 12131-12134.

(3) Jun Li, Ke Yi,Yanli Lei,* Zhihe Qing, Zhen Zou, Yuedong Zhang, Haiyan Sun, Ronghua Yang*. Al centre-powered graphitic nanozyme with high catalytic efficiency for pH-independent chemodynamic therapy of cancer.Chemical Communications, 2020, 56, 6285.

4Yanli Lei, Zhenzhen Qiao, Jinlu Tang, Xiaoxiao He, Hui Shi,* Xiaosheng Ye, Lv’an Yan, Dinggeng He and Kemin Wang*. DNA nanotriangle-scaffolded multivalent activatable aptamer probe with ultralow background and robust stability for cancer theranostics.Theranostics, 2018, 8, 4062-4071.

5Yanli Lei, Jinlu Tang, Hui Shi,* Xiaosheng Ye, Xiaoxiao He,* Fengzhou Xu, Lv’an Yan, Zhenzhen Qiao and Kemin Wang*. Nature-inspired smart DNA nanodoctor for activatable in vivo cancer imaging and in situ drug release based on recognition-triggered assembly of split aptamer.Analytical Chemistry, 2016, 88, 11699-11706.


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