科研情况: ◉主要研究方向: 1、多功能核酸纳米球合成; 2、纳米发光材料的绿色合成; 3、生物传感器在生物检测及医学应用。 ◉近5年科研项目: 1、国家自然科学基金应急项目(21645009),多功能DNA核酶荧光胶束对细胞内信使RNA成像及基因治疗研究,执行时间:2017.01-2017.12;结题,主持。 2、湖南省自然科学基金面上项目(2018JJ2419),多功能核酶-纳米囊泡对乳腺肿瘤细胞成像及基因治疗研究,执行时间:2018.1-2020.12;结题,主持。 ◉近5年科研论文: 1.Jing-LinHe*,YangZhang,Ting-TingMei,LingTang,Si-YingHuang,ZhongCao*.Telomerase-triggered DNAzyme spiders for exponential amplified assay ofcancer cells.Biosensors and Bioelectronics,2019,144,111692. 2.Jing-Lin He*,Yang Zhang,Chan Yang,Si-Ying Huang,Ling Wu,Ting-Ting Mei,Jianxiu Wang,Zhong Cao*. Hybridization chain reaction basedDNAzymefluorescent sensor for L-histidine assay.AnalyticalMethods, 2019,11, 2204. 3.Jing-Lin He*, Xing-Xing Wang, Ting-Ting Mei, Ling Wu, Ju-Lan Zeng, Jian-Hui Wang, Jianxiu Wang, Donghong Yu and Zhong Cao*,DNA-templated copper nanoclusters obtained via TdT isothermal nucleic acid amplification for mercury(II) assay.Anal. Methods, 2019,11, 4165 4.Jing-Lin He*,Ting-Ting Mei,Ling Tang,Shi-Qing Liao,Zhong Cao*, DSN/TdT recycling digestion based cyclic amplification strategy formicroRNA assay.Talanta 219 (2020) 121173 ◉专利与成果转化: 1、何婧琳;微电极生物传感器及其在检测端粒酶中的应用,2020-04-28,中国,ZL201810040231.3. 2、何婧琳;基于DNA-银纳米簇检测癌细胞的靶向荧光探针及应用,2021-02-19,中国,ZL201810332674.X. |